microsatelliteinstabilitytest

This test is typically run in conjunction with immunohistochemical staining for mismatch repair proteins, performed by the UCSF Pathology Laboratory.

Screening test for Lynch syndrome. Use to determine potential eligibility for immunotherapy by identifying microsatellite instability-high (MSI-H) cancers.

MSI or microsatellite instability testing is used to assess whether someone has the genetic mutations or variants that cause Lynch syndrome.

由 H Kawakami 著作 · 2015 · 被引用 441 次 — MSI testing can be performed on fresh, frozen or paraffin-embedded tumor tissue using a PCR-based assay for detection of instability (3, 4). The National Cancer ...

由 BL Sun 著作 · 2021 · 被引用 40 次 — The National Comprehensive Cancer Network (NCCN) 2018 guidelines recommended microsatellite instability (MSI) testing or mismatch repair (MMR) protein analysis ...

MSI testing looks at the length of certain DNA microsatellites from the tumor sample to see if they have gotten longer or shorter as a measure of instability.

There are several methods that can be used to detect microsatellite instability (MSI) or deficient DNA mismatch repair (dMMR). The two most common methods ...

由 K Li 著作 · 2020 · 被引用 348 次 — Clinically, MSI can be detected by detecting changes in microsatellite sequences, or by detecting whether four MMR proteins are missing to ...

由 W Kohlmann 著作 · 2018 · 被引用 1 次 — Figure 1. Microsatellite instability testing is used to identify tumors caused by defective MMR by comparing the number of nucleotide repeats in a panel of ...